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There was a significant between-study heterogeneity ( I 2 = 539 %, P = 0034) in which the study location and duration of studies were revealed as the sources of heterogeneity following subgroup analysis

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These abnormalities may partially explain why PLS patients are prone to severe periodontitis ( However, notably, PLS patients resistance to most common infections usually remains within normal ranges, indicating that basic antibacterial defense mechanisms remain intact ( 7.2 Safety data from clinical studies Current studies indicate that both NSP inhibitory effects and skin symptom occurrence require high levels of DPP1 inhibition ( In clinical trials of DPP1 inhibitors, all three major DPP-1 inhibitors showed similar safety characteristics, including low incidence rates of skin hyperkeratosis and periodontal events, consistent with the mechanism of action of DPP-1 inhibition

Time will tell, thats for sure